A Cross-sectional Study to Assess Insulin Resistance and Atherogenic Index of Plasma as Predictors of Risk of Cardiometabolic Disease among Undergraduate Medical Students at a Tertiary Care Teaching Hospital, Karnataka
A Cross-sectional Study to Assess Insulin Resistance and Atherogenic Index of Plasma as Predictors of Risk of Cardiometabolic Disease among Undergraduate Medical Students at a Tertiary Care Teaching Hospital, Karnataka
Blog Article
Background: Medical profession is known for stress and challenges due to hectic academic schedules which makes students, high-risk candidates for diabetes mellitus, hypertension and cardiometabolic disease (CMD).Surrogate markers such as homeostatic model assessment insulin resistance (HOMA-IR) and atherogenic index of plasma (AIP) along with routine parameters enable early prediction of the disease.Hence, this study aimed at determining HOMA-IR and AIP along with assessment of their correlation with anthropometric and biochemical parameters associated with CMD risk among undergraduate medical students.Methodology : 460 medical students consented to participate in the study.The data related to socio-demographic profile, anthropometry, blood pressure and biochemical CD parameters such as fasting plasma glucose (FPG), fasting plasma insulin (FPI) and lipid profile was collected and analyzed.
HOMA-IR and AIP were calculated.The strength of association between study variables was determined by relevant statistics.Results: The study showed the prevalence of overweight (17.8%), obesity (20.4%), pre-hypertension (37.
82%) and hypertension (3.47%).98.5% of the participants had normal FPG and FPI, whereas 1.5% had impaired levels.
Lipid profile analysis showed hypercholesterolemia (3.7%), hypertriglyceridemia (8.1%), increased LDL-c (33.7%) and reduced HDL-c (55.2%).
High HOMA-IR and AIP were contributed by 28.9% and 73.3% respectively.HOMA-IR and AIP showed statistically significant positive correlation with CMD risk factors.Conclusion: HOMA-IR and AIP considered as the better predictors of CMD risk among apparently healthy medical students.
Thus, incorporation of these surrogate markers along with routine parameters for Maschera Mani/Piedi regular screening can help in early prediction of the risk of CMD among undergraduate medical students.Keywords: Homeostatic model assessment insulin resistance, Atherogenic index of plasma, Cardiometabolic disease, Medical students.